Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice

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Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice.

Morphine analgesic tolerance is heritable in both humans and rodents, with some individuals and strains exhibiting little and others exhibiting robust tolerance. 129S6/SvEv and 129P3/J mice reportedly do not demonstrate tolerance to morphine analgesia. Using our laboratory's standard morphine tolerance regimen and a between-subjects design, tolerance developed in the hot plate and tail withdraw...

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ژورنال

عنوان ژورنال: Pharmacology Biochemistry and Behavior

سال: 2006

ISSN: 0091-3057

DOI: 10.1016/j.pbb.2006.11.012